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In addition, a high-sugar diet increases nuclear 25-hydroxycholesterol (25HC) to activate DNMT1, which regulates cell lipid metabolism genes through DNA methylation, contributing to MAFLD and metabolic syndrome (54)

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Dialectical Behavior Therapy (DBT): DBT addresses the emotional dysregulation and interpersonal deficits that frequently co-occur with stimulant and hallucinogen use disorders, providing distress tolerance and emotional regulation skills that reduce relapse risk